Pierre Guerin 1000L Fermenter

This listing is for the Pierre Guerin 1000L Fermenter.

The unit is in full working condition and is ready for immediate use.

Overview

The Pierre Guerin 1000L Fermentation System is a high-capacity, stainless steel bioreactor/fermenter engineered for process development, scale-up, and clinical or commercial production. With a working volume of approximately 700–800 litres, this system bridges pilot and production scale, delivering robust performance, exceptional process control, and full compliance with GMP and FDA requirements. Built by Pierre Guerin, a global leader in sanitary stainless steel process systems, the 1000L fermenter is ideal for demanding applications in biotech, pharmaceutical, food, and industrial biotechnology sectors.

Key Features

Advanced Bioprocess Control

Automated Regulation: Precise control of pH, DO, temperature, agitation, antifoam, and feeding, with optional cascade control strategies.

SCADA Integration: Seamless connectivity with Siemens, DeltaV, or Rockwell Automation for full process automation and data logging.

Sterile Processing: Designed for SIP (Steam-in-Place) and CIP (Clean-in-Place) operation for maximum sterility and cleanability.

Robust, Hygienic Design

1000L Total Volume with up to 800L working volume, ideal for late-stage development and pre-commercial production.

316L Stainless Steel Vessel: Internal surfaces electropolished to Ra ≤ 0.6 μm for hygienic and corrosion-resistant performance.

Jacketed Construction: Provides accurate temperature control via integrated thermal fluid systems.

Technical Specifications

Model: Pierre Guerin 1000L Fermentation System

Total Volume: 1000 liters

Working Volume: Approx. 700–800 liters

Vessel Material: 316L stainless steel

Surface Finish: Ra ≤ 0.6 µm (electropolished), optional ASME BPE compliance

Sterilization: Fully SIP-capable

Agitation: Top- or bottom-mounted agitator with mechanical seal

Temperature Control: Jacketed vessel with PID regulation

Sensor Ports: For pH, DO, temperature, level, pressure, and foam control

Applications

Pharmaceuticals: Production of therapeutic proteins, enzymes, and vaccines

Biotechnology: Cultivation of microbial, yeast, or mammalian cells

Food & Beverage: Probiotics, fermentation-derived ingredients

Industrial Biotech: Fermentation of biofuels, organic acids, and fine chemicals

R&D and Pilot Production: Seamless scale-up from lab-scale to commercial batches

System Components

1000L jacketed stainless steel fermenter with dished head and conical bottom

High-efficiency agitator with variable speed drive

Integrated control system with touchscreen HMI

Gas flow regulation via MFCs (Air, O₂, CO₂, N₂)

Foam and level control with automated dosing

Sampling valve, exhaust condenser, and sterile utility connections

CIP/SIP spray devices and drainable piping

Quality Assurance

Pierre Guerin systems are designed and built to meet global regulatory standards including GMP, FDA, and ASME BPE. Each system undergoes rigorous FAT (Factory Acceptance Testing) and can be delivered with full IQ/OQ documentation, 3.1 material certificates, and orbital weld documentation.

Benefits

High Productivity: Large working volume supports batch, fed-batch, or continuous processes

Scalable Design: Mimics lab-scale conditions to ensure reliable scale-up

Superior Cleanability: Full CIP/SIP compatibility and sanitary design

Automation-Ready: Compatible with advanced control platforms

Regulatory Compliance: Built for use in validated, GMP-regulated environments

Conclusion

The Pierre Guerin 1000L Fermentation System delivers high-performance, scalable bioprocessing for organizations ready to advance from pilot to production. With robust construction, precise control, and full regulatory compliance, it is the ideal solution for producing biologics, active ingredients, and other fermentation-based products at scale.